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After working at the U of M for 25 years, I had many opportunities to capture the beautiful campus surroundings (click on Work Area Photos in Lr).

I have contributed to various publications which I have listed. In addition, you can find my publications on Research Gate


Publication List 

Click on the underlined text to view the PDF document. Articles are copyrighted and may not be used without permission. 


45. Autry, JM, CB Karim, S Perumbakkam, CJ Finno, EC McKenzie, DD Thomas, and SJ Valberg. 2020. Sarcolipin Exhibits Abundant RNA Transcription and Minimal Protein Expression in Horse Gluteal Muscle. Vet Sci 7:178.

PMID: 3320283

44. Autry, JM, CB Karim, M Cocco, SF Carlson, DD Thomas, and SJ Valberg. 2020. Purification of sarcoplasmic reticulum vesicles from horse gluteal muscle. Analyt Biochem 610:113965. PMID: 32956693



43. Cheng Her, Andrew R. Thompson, Christine B. Karim & David D. Thomas. 2018. Structural dynamics of calmodulin-ryanodine receptor interactions: electron paramagnetic resonance using stereospecific spin labels.  Sci Rep. 2018 Jul 16;8(1):10681. doi: 10.1038/s41598-018-29064-8. PMID: 30013092 



42. Her, C, JE McCaffrey, DD Thomas, and CB Karim. 2016. Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin. Biophys J, 111(11): 2387-2394. PMID: 27926840

41. Lewis AK, Valley CC, Peery SL, Brummel B, Braun AR, Karim CB, Sachs JN. 2016. Death Receptor 5 Networks Require Membrane Cholesterol for Proper Structure and Function. J Mol Biol, Dec 4; 428: 4843-4855. PMID 27720987

40. Lewis AK, K Dunleavy, TL Senkow, C Her, BT Horn, MA Jersett, R Mahling, MR McCarthy, GT Perell, CC Valley, CB Karim, J Gao, WC Pomerantz, DD Thomas, A Cembran, A Hinderliter, and JN Sachs. 2016. Oxidation increases the strength of the methionine-aromatic interaction. Nature Chem Biol, 12(10):860-6. PMID 27547920



39. Karim CB, Espinoza-Fonseca LM, James ZM, Hanse EA, Gaynes JS, Thomas DD, Kelekar A. 2015. Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation. Sci Rep. 2015 Sep 28;5:14557.doi: 10.1038/srep14557. Erratum in: Sci Rep. 2015;5:15872. PMID: 26411306



38. Ablorh, N-A, X Dong, ZM James, Q Xiong, J Zhang, DD Thomas, and CB Karim. 2014. Synthetic Phosphopeptides Enable Quantitation of the Content and Function of the Four Phosphorylation States of Phospholamban in Cardiac Muscle. J Biol Chem. Oct 17;289(42):29397-405. PMID: 25190804

37. Andrew K. Lewis, Zachary M. James, Jesse E. McCaffrey, Anthony R. Braun, Christine B. Karim, David D. Thomas, and Jonathan N. Sachs. 2014. Open and Closed Conformations of the Isolated Transmembrane Domain of Death Receptor 5 Support a New Model of Activation. Biophys J. 106: L21–L24. PMID: 24655519


36. James, Z, JE McCaffrey, KD Torgersen, CB Karim, and DD Thomas. 2012. Protein-Protein Interactions in Calcium Transport Regulation Probed by Saturation Transfer Electron Paramagnetic Resonance. Biophys J. 103(6):1370-1378. PMID: 22995510

35. Valley CC, Lewis AK, Mudaliar DJ, Perlmutter JD, Braun AR, Karim CB, Thomas DD, Brody JR, Sachs JN. 2012. Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Induces Death Receptor 5 Networks That Are Highly Organized. J Biol Chem. 15;287(25):21265-78. PMID: 22496450

34. Li J, James ZM, Dong X, Karim CB, Thomas DD. 2012. Structural and Functional Dynamics of an Integral Membrane Protein Complex Modulated by Lipid Headgroup Charge. J Mol Biol. 418(5):379-89. PMID: 22381409


33. Ablorh NA, Miller T, Nitu F, Gruber SJ, Karim C, Thomas DD. 2011. Accurate quantitation of phospholamban phosphorylation by immunoblot. Anal Biochem. 425(1): 68-75. PMID: 22369895

32. Lockamy EL, Cornea RL, Karim CB, Thomas DD. 2011. Functional and physical competition between phospholamban and its mutants provides insight into the molecular mechanism of gene therapy for heart failure. Biochem Biophys Res Commun. 408(3):388-392. PMID: 21510919

31. Gustavsson M, Traaseth NJ, Karim CB, Lockamy EL, Thomas DD, Veglia G. 2011. Lipid-Mediated Folding/Unfolding of Phospholamban as a Regulatory Mechanism for the Sarcoplasmic Reticulum Ca2+ ATPase. J Mol Biol. 408(4):755-765. PMID: 21419777



30. Lowman XH, McDonnell MA, Kosloske A, Odumade OA, Jenness C, Karim CB, Jemmerson R, Kelekar A. 2010. The Proapoptotic Function of NOXA in Human Leukemia Cells Is Regulated by the Kinase Cdk5 and by Glucose. Mol Cell. 40(5):823-833. PMID: 21145489



29. Becucci L, Guidelli R, Karim CB, Thomas DD, Veglia G. 2009. The Role of Sarcolipin and ATP in the Transport of Phosphate Ion into the Sarcoplasmic Reticulum. Biophys J. 97(10):2693-2699. PMID: 19917222

28. Becucci L, Cembran A, Karim CB, Thomas DD, Guidelli R, Gao J, Veglia G. 2009. On the Function of Pentameric Phospholamban: Ion Channel or Storage Form? Biophys J. 96(10):L60-62. PMID: 19450461



27. Xi X, Sun Y, Karim CB, Grigoryants VM, Scholes CP. 2008. HIV-1 Nucleocapsid Protein NCp7 and its RNA Stem Loop 3 Partner: Rotational Dynamics of Spin-Labeled RNA Stem Loop 3. Biochemistry. 47(38):10099-10110.

PMID: 18729386

26. Zhang Z, Xi X, Scholes CP, Karim CB. 2008. Rotational dynamics of HIV-1 nucleocapsid protein NCp7 as probed by a spin label attached by peptide synthesis. Biopolymers. 89(12):1125-1135. PMID: 18690667


25. Ha NK, Traaseth NJ, Verardi R, Zamoon J, Cembran A, Karim CB, Thomas DD, Veglia G. 2007. Controlling the inhibition of the sarcoplasmic Ca2+-ATPase by tuning phospholamban structural dynamics. J Biol Chem. 282(51):37205-37214. PMID: 17908690 

24. Traaseth, NJ., Verardi R, Torgersen KD, Karim CB, Thomas DD, and Veglia G. 2007. Spectroscopic validation of the pentameric structure of phospholamban. Proc Nat Acad Sci USA. 104(37):14676-14681. PMID: 17804809

23. Becucci L, Guidelli R, Karim CB, Thomas DD, Veglia G. 2007. An electrochemical investigation of sarcolipin reconstituted into a mercury-supported lipid bilayer. Biophys J. 93(8):2678-2687. PMID: 17586575

22. Nesmelov YE, Karim CB, Song L, Fajer PG, Thomas DD. 2007. Rotational dynamics of phospholamban determined by multifrequency electron paramagnetic resonance. Biophys J. 93(8): 2805-2812. PMID: 17573437

21. Karim CB, Zhang Z, Thomas DD. 2007. Synthesis of TOAC spin-labeled proteins and reconstitution in lipid membranes. Nat Protoc. 2(1):43-49. PMID: 17401337

20. Zhang Z, Remmer HA, Thomas DD, Karim CB. 2007. Backbone dynamics determined by electron paramagnetic resonance to optimize solid-phase peptide synthesis of TOAC-labeled phospholamban. Biopolymers. 88(1):29-35. PMID: 17066471



19. Karim CB, Zhang Z, Howard EC, Torgersen KD, Thomas DD. 2006. Phosphorylation-dependent conformational switch in spin-labeled phospholamban bound to SERCA. J Mol Biol. 358(4):1032-1040. PMID: 16574147



18. Zamoon J, Nitu F, Karim C, Thomas DD, Veglia G. 2005. Mapping the interaction surface of a membrane protein: unveiling the conformational switch of phospholamban in calcium pump regulation. Proc Natl Acad Sci USA. 102(13):4747-4752. PMID: 15781867



17. Karim CB, Kirby TL, Zhang Z, Nesmelov Y, Thomas DD. 2004. Phospholamban structural dynamics in lipid bilayers probed by a spin label rigidly coupled to the peptide backbone. Proc Natl Acad Sci USA. 101(40):14437-14442.

PMID: 15448204

16. Mueller B, Karim CB, Negrashov IV, Kutchai H, Thomas DD. 2004. Direct detection of phospholamban and sarcoplasmic reticulum Ca-ATPase interaction in membranes using fluorescence resonance energy transfer. Biochemistry. 43(27):8754-8765. PMID: 15236584

15. Kirby TL, Karim CB, Thomas DD. 2004. Electron paramagnetic resonance reveals a large-scale conformational change in the cytoplasmic domain of phospholamban upon binding to the sarcoplasmic reticulum Ca-ATPase. Biochemistry. 43(19):5842-5852. PMID: 15134458



14. Buck B, Zamoon J, Kirby TL, DeSilva TM, Karim C, Thomas D, Veglia G. 2003. Overexpression, purification, and characterization of recombinant Ca-ATPase regulators for high-resolution solution and solid-state NMR studies. Protein Expr Purif. 30(2):253-261. PMID: 12880775

13. Lockwood NA, Tu RS, Zhang Z, Tirrell MV, Thomas DD, Karim CB. 2003. Structure and function of Integral membrane protein domains resolved by peptide-amphiphiles: application to phospholamban.

Biopolymers. 69(3):283–292. PMID: 12833255



12. Mascioni A, Karim C, Zamoon J, Thomas DD, Veglia G. 2002. Solid-state NMR and rigid body molecular dynamics to determine domain orientations of monomeric phospholamban. J Am Chem Soc. 124(32):9392-9393.

PMID: 12167032

11. Mascioni A, Karim C, Barany G, Thomas DD, Veglia G. 2002. Structure and orientation of sarcolipin in lipid environments. Biochemistry. 41(2):475-482. PMID: 11781085



10. Karim CB, Paterlini MG, Reddy LG, Hunter GW, Barany G, Thomas DD. 2001.Role of cysteine residues in structural stability and function of a transmembrane helix bundle. J Biol Chem. 276(42):38814-38819. PMID: 11477077

9. Hellstern S, Pegoraro S, Karim CB, Lustig A, Thomas DD, Moroder L, Engel L. 2001. Sarcolipin, the Shorter Homologue of Phospholamban, Forms Oligomeric Structures in Detergent Micelles and in Liposomes. J Biol Chem. 276(33):30845-30852. PMID: 11413134



8. Karim CB, Marquardt CG, Stamm JD, Barany G, Thomas DD. 2000. Synthetic Null-CysteinePhospholamban Analogue and the Corresponding Transmembrane Domain Inhibit the Ca-ATPase. Biochemistry. 39(35):10892-10897.

PMID: 10978176

7. Karim CB, Reddy LG, Hunter GW, Angell YM, Barany G, Thomas DD. 2000. Chemical approach for evaluating role of the cysteine residues in pentameric phospholamban structure: Effect on sarcoplasmic reticulum Ca2+-ATPase. Peptides for the New Millennium. American Peptide Symposia. 6:381-382.



6. Karim CB, Stamm JD, Karim J, Jones LR, Thomas DD. 1998. Cysteine reactivity and oligomeric structures of phospholamban and its mutants. Biochemistry. 37(35):12074-12081. PMID: 9724519

5. Thomas DD, Reddy LG, Karim CB, Li M, Cornea R, Autry JM, Jones LR, Stamm J. 1998. Direct spectroscopic detection of molecular dynamics and interactions of the calcium pump and phospholamban. Ann N Y Acad Sci. 853: 186-194. PMID: 10603946



4. Steinhoff H-J, Karim CH. 1993. Protein Dynamics and EPR spectroscopy: Comparison of Molecular Dynamics Simulation with Experiments.

Ber Bunsen Ges Phys Chem 97:163-171. 



3. Steinhoff H-J, Dombrowsky O, Karim C, Schneiderhahn C. 1991. Two dimensional diffusion of small molecules on protein surfaces: an EPR study of the restricted translational diffusion of protein-bound spin labels. Eur Biophys J. 20(5): 293-303. PMID: 1664324



2. Karim, C.B., R. Philipp, W.E. Trommer, and J.H. Park. 1989. Interaction of Glyceraldehyde-3-phosphate Dehydrogenase with AMP as Studied by Means of a Spin-labeled Analog. Biol. Chem., Hoppe-Seyler 370: 1245-1252.  PMID: 2559743



1. Karim, C, Beth AH, Fleischer S, McIntyre JO, Mink R, Park JH, Robinson BH, Wilder RT, Trommer WE. 1986. Studies of structure function relationships in dehydrogenases by means of the spin-labeling technique. Biol Chem Hoppe Seyler. 367:88.

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